The 'Review of the MEPAG Report on Mars Special Regions' is the final report (in prepublication format) of the Committee to Review the MEPAG Report on Mars Special Regions, a joint activity between the National Academies of Sciences, Engineering, and Medicine and the European Science Foundation. The joint committee was established to review the current planetary protection requirements for Mars Special Regions and their proposed revision as outlined in the 2014 Special Regions (SR-SAG2) report of the Mars Exploration Program Analysis Group (MEPAG). The resulting report from the review includes recommendations to NASA, the European Space Agency (ESA) and COSPAR for an update of the planetary protection requirements for Special Regions.