The Project
A systems biology approach to mitosis.
Winner
Daniel Gerlich
ETH Zurich
Institute of Biochemistry
Zurich, Switzerland
Since mid 2002, German national Daniel Gerlich, 33 years old, has been a postdoctoral fellow at the European Molecular Biology Laboratory in Heidelberg, Germany. Gerlich's academic and scientific achievements include a summa cum laude grade for his dissertation on the dynamics of nuclear architecture investigated by live cell microscopy and quantitative 4-D reconstruction. He is a frequent speaker at scientific conferences and events and is the author or co-author of 15 published research papers.
Award
€1,016,750
Project Description
In this project, an integrated strategy combining automated confocal microscopy, RNA interference, quantative image processing and mathematical modelling will be established to study the function of complex protein networks in human cells.
As an initial application, systematic analysis of mitosis-relevant genes in single live cells will lead to the construction of mathematical models that will be used to address reaction kinetics of functional modules in human cells.
A better understanding of mitotic regulation at the systems level will, in the long run, contribute to the development of strategies to fight cancer.
