ESF Research Conferences

ESF-EMBO Symposium

Glutathione and Related Thiols in Living Cells

4-9 September 2011

Final Programme

Sunday 4 September
17:00–19:30Registration at the ESF Desk                                                                                           
19.30
Welcome Drink
20.00
Dinner
Monday  5 September
08.45-09.00

Conference Opening and Welcome Message from the Chair, Joris Messens

09.00-09.40 Bob Buchanan, University of California, US
Thioredoxin and Redox Regulation Reach Out to the Third Domain of Life
Session I -  Redox signaling and regulation
Chair:  Elias Arnér, Karolinska Institutet, SE
09.40-10.20 Jonathan Stamler, Institute for Transformative Molecular Medicine, Case Western Reserve University and University Hospitals, US
Paradigms for Protein S-nitrosylation and Denitrosylation     
10.20-10.40 Katarina Johansson, Karolinska Institutet, SE
Expanding the Knowledge of Redox Regulation - Development of Tools to Simultaneously Determine Key Transcription Factor Activities in Individual Cells
10.40-11.00

Coffee break

11.00-11.40
Sue Goo Rhee, Ewha Womans University , KR
Intracellular Messenger Function of Hydrogen Peroxide and Its Regulation via Peroxiredoxin
11.40-12.20
Stuart Lipton, Sanford|Burnham Medical Research Institute, US
Transnitrosylation of XIAP Regulates Caspase-Dependent Neuronal Cell Death
12.20 -12.40
Aeid Igbaria, CEA Saclay, FR
The function of glutathione in eukaryotic cells and its cellular compartmentation
13:00 -15:00
Lunch
15.00-17.00
Poster session with Coffee 

Session II – Antioxidants defense by low molecular weight thiols
Chair: Katja Becker, Giessen University, DE

17.00-17.40

Luise Krauth-Siegel, Universität Heidelberg, DE
Hydroperoxide detoxification in the unique trypanothione metabolism of African trypanosomes

17.40-18.20Alfonso Pompella, University of Pisa, IT
Cellular and soluble gamma-glutamyltransferase: glutathione, thiols and beyond
18.20-18.40
Koen Van Laer, Brussels Center for Redox Biology, VIB-VUB, BE
The mycoredoxin-1 defense mechanism against oxidative stress in Mycobacterium tuberculosis
18.40-19.00Chris Hamilton, University of East Anglia, UK
The chemical thiology of bacillithiol: An unique biothiol in B. anthracis, B. cereus, S. aureus and other Low G+C Gram positive bacteria
19:15 - 21:00 
Dinner
21:00 - 23:00
Poster session and open bar
Tuesday 6 September
Session III – Thiol-based catalysis and oxidative stress
Chair: Joris Messens, VIB Department Structural Biology, BE
09.00-09.40   Leslie Poole, Wake Forest School of Medicine, US
Investigation of biologically-relevant protein oxidation
10:00–10:30    Coffee Breakand Group Picture
09.40-10.20 Lars Hederstedt, Lund University, SE
Extracytoplasmic protein disulfide bond management in the Gram-positive bacterium Bacillus subtilis
10.20-10.40  
Kostas Tokatlidis, Institute of Molecular Biology and Biotechnology, GR
Chaperone-induced folding, a novel targeting signal and substrate mimicry control redox trapping and recycling in mitochondria
10:40–11:00
Coffee Break ad Group Photo       
11.00-11.40
Ursula Jakob,  University of Michigan, US   
Oxidative Stress and Redox Regulation
11.40-12.00Katleen Denoncin, Brussels Center for Redox Biology, de Duve Institute, WELBIO-UCL, BE
Redox regulation of the periplasmic L-arabinose binding protein
12.00-12.20
Ester Zito, University of Cambridge, UK
Redundancy of disulfide oxidases in mammals
12:30 - 14:30Lunch
15.00-17.00 Poster session with Coffee
Session IV: Iron sulfur and Thiol conjugates
Chair: Roland Lill, Philipps Universität Marburg, DE
17.00-17.40  Christopher Lillig, University Marburg, DE
Glutaredoxins at the intersection of redox regulation and iron homeostasis
17.40-18.20
Nicolas Rouhier, Nancy University, FR
Investigating redox- and iron-sulfur cluster-related functions of plant monothiol glutaredoxins
18.20-18.40
Carsten Berndt, Karolinska Institute, SE
The role of dithiol Glutaredoxins during embryonic development and differentiation
18.40-19.00 
Caryn Outten, University of South Carolina, US
Sensing and Regulating Intracellular Iron Using GSH and Fe-S Clusters
19:15 - 21:00 
Dinner
21:00 - 23:00
Poster session and open bar
Wednesday 7 September
Session V – Redox Structural Biology
Chair: Leslie Poole, Wake Forest School of Medicine, US
09.00-09.40
Jenny Martin, University of Queensland, AU
Targeting bacterial redox proteins to develop compounds with antivirulence  activity
09.40-10.20 Todd Lowther, Wake Forest School of Medicine, US
Molecular mechanism of the repair of hyperoxidized peroxiredoxins by sulfiredoxin
10.20-10.40   
Kenji Inaba, Kyushu University, JP
Structure and mechanism of the protein disulfide formation systems in human cells
10:40-11:00
Coffee break
Session VI – Folding
Chair: Johannes Herrmann, University of Kaiserslautern, DE
11.00-11.40 Agnieska Chacinska, International Institute of Molecular and Cell Biology, PL
Disulfide bond formation in mitochondria – nothing by chance
11.40-12.20        Neil Bulleid, University of Glasgow, UK
Lecture to be announced
12.20-12.40    Jan Riemer, University of Kaiserslautern, DE
Oxidative folding in mitochondria of mammalian cells
13:00 
Lunch
15:00        Excursion
19:30 Get together Drink and Conference Dinner
Thursday 8 September
Session VII – Redoxins
Chair: John Mieyal, Case Western Reserve University, US
09.00-09.40        Sabine Zachgo, University of Osnabrück, DE
ROXYs: glutaredoxins and flower development
09.40-10.20Junji Yodoi, Kyoto University, JP
Anti-Inflammatory redox regulation  by Redoxisome with  thioredoxin/TRX and TBP-2/TXNIP/VDUP-1
10.20-10.40 Elizabeth Veal, Newcastle University, UK
Responding to stress; peroxiredoxins as regulators of stress responses and ageing
10.40-11.00     Coffee break
Session VIII Redox Technologies
Chair: Lars Leichert, Ruhr-University Bochum, DE
11.00-11.40    Kate Carroll, The Scripps Research Institute, US
Painting the Cysteine Chapel: New Tools to Probe Oxidat
11.40-12.20       Merridee Wouters, Deakin University, AU
Identifying components of thiol-based signalling pathways: computational approaches
12.20-12.40        Pablo Martinez-Acedo, CBMSO - CSIC/UAM, ES
GELSILOX: simultaneous high-throughput identification and quantification of thiol redox state and total proteomes
13:00    Lunch
15.00-17.00 
Poster session with Coffee
Forward Look
Chair: Arne Holmgren, Karolinska Institute, SE
17.00-17.20    Karl Josef Dietz, University of Bielefeld, DE
The chloroplast 2-Cys peroxiredoxin as a redox regulatory hub in the chloroplast
17.20-18.20    Frederico Pallardo, University of Valencia, ES
Role of nuclear glutathione in the control of cell
18.20-19.20        Leopold Flohé, Otto-von Guericke-Universität Magdeburg, DE
Changing paradigms in thiol redoxology
19:30 - 21:00  Dinner
21:00 - 23:00
Poster session and open bar
Friday 9 September

Breakfast and Departure