Molecular Level Physiology and Pathology of Oxidised Phospholipids (OXPL)
The OXPL consortium represents a highly focused, integrated interdisciplinary approach of European research laboratories already active in this now rapidly emerging area in biological chemistry, together with additional skills brought into the project by groups representing state-of-the-art expertise in method and high resolution instrumentation development for the characterization of biomolecules, their interactions in biomembranes, and localization in cells.
More specifically, this project combines leading edge expertises on membrane biophysics, from modern MD simulations to a range of experimental techniques (ellipsometry, Langmuir troughs, FCS, AFM, NMR), all the way to protein folding, molecular cell biology, imaging, chemical biology, and lipidomics analyses. The project will pave the way to the development of improved diagnostics, therapies and preventive measures to combat the above diseases, and will take European research to the leading edge in this rapidly emerging and important area.
Project Leader:
Professor Paavo Kinnunen, University of Helsinki, Helsinki, Finland
Project Investigators:
- Professor Albin Hermetter, Graz University of Technology, Graz, Austria
- Dr. Gerhard Schütz, Joannes Kepler University Linz, Austria
- Professor Thorsten Hugel, Technical University of Munich, Garching, Germany
- Professor Martin Hof, Academy of Sciences of the Czech Republic, Prague, Czech Republic
- Professor Pavel Jungwirth, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Associated Partners:
- Dr. Corinne Spickett, University of Strathclyde, Glasgow, United Kingdom
- Dr. Himanshu Khandelia, University of Southern Denmark, Odense, Denmark
- Dr. Franscesco Megli, University of Bari, Italy
- Professor Gerhard Gröbner, Umea University, Sweden
- Dr. Ingela Parmryd, The Wenner-Gren Institute, Stockholm University, Sweden
