Spacio-temporal organization of the synaptic membrane for synaptic vesicle protein recycling (SYNAPSE)
The presynaptic terminal contains clusters of synaptic vesicles, key organelles of chemical neurotransmission. Proteomics data indicate that theses vesicles comprise distinct sets of proteins and lipids present in defined stoichiometries which must be maintained during repetitive rounds of exo- and endocytosis. How this precise sorting of the synaptic vesicles membrane proteins is accomplished molecularly is not well understood.
How the spatio-temporal dynamics of endocytic proteins at the nerve terminal are controlled is largely unknown but likely involves membrane-associated multidomain scaffolding proteins organizing the periactive zone. The work of this project aims to tackle these problems and will thus enable us to gain unprecedented insights into the spatio-temporal organization of the synaptic membrane for clathrin-mediated synaptic vesicles protein recycling.
Project Leader:
Professor Volker Haucke, Free University Berlin, Germany
Principal Investigators:
Professor Oleg Shupliakov, Center of Excellence in Developmental Biology Karolinska Institutet, Stockholm, Sweden
Dr. Jürgen Klingauf, Max Plank Institute for Biolophysical Chemistry, Göttingen, Germany
Professor Pekka Hänninen, University of Turku, Finland
